The terms “cancer” and “tumor” refer to a pathological condition characterized by the uncontrolled proliferation of cells that have the ability to infiltrate normal organs and tissues of the body, altering their structure and function. Cancer also has the ability to localize remotely from the primary disease, and in this case, it is referred to as secondary or metastatic disease. Tumours are divided into solid tumours, characterized by a compact mass of tissue, and blood tumours (e.g., lymphomas and leukaemias).

WHAT IS CANCER?
umours can be classified in various different ways, depending on the organ in which they develop, the type of cells that are formed, the stage at which the disease is diagnosed, its
aggressiveness, and the possibility of metastasis development.

WHAT ARE THE CAUSES OF CANCER?
Cancer is caused by mutations in the DNA within cells. Cellular DNA contains information on how cells should grow and multiply. Errors in these instructions cause the cell to become cancerous. Genetic mutations can lead a healthy cell to:

  • Multiply abnormally, thereby creating a greater number of diseased cells. Fail to counteract abnormal cell growth: normal cells contain genes called tumour suppressors,
    which recognize abnormal cell growth and act to stop it. When there is an error in these genes, this function can be weakened or even interrupted. This allows mutated cells to continue to grow and divide.
  • Make mistakes in DNA repair: genes are able to identify and repair any errors present within the DNA itself. A mutation may result in some errors going undetected, allowing for the accumulation of different mutations and, ultimately, the appearance of cancer. Genetic mutations can be present from birth, or in other cases, they may be caused by viruses,
    chronic inflammation, or the hormones produced by the body. However, they can also be caused by factors external to the body, such as ultraviolet (UV) rays, carcinogenic chemicals, or radiation. Scientists believe that the simultaneous presence of more than one mutation is necessary for most tumours to develop. Some hematologic tumours can arise from a single mutation, but most tumours that form in internal organs, such as lungs and colon, arise from many different mutations. It is still unclear how many mutations must accumulate to give rise to a tumour, although it is believed that this varies depending on the type of tumour. Genetic mutations present at birth combine with those acquired over time to give rise to cancer. This means that mutations present at birth are necessary but not sufficient for the development of cancer. One or more additional mutations will be required to cause the tumour.

THE TUMOR: WHAT ARE THE SYMPTOMS?
Genetic mutation only makes it more likely that a person will develop cancer when exposed to other risk factors. Mutations initiate the process, while risk factors play a role in the
development of the disease. Cancer can, therefore, be defined as a multifactorial disease in which genetic mutations and environmental factors play fundamental roles.
What are the symptoms of cancer? Each type of tumour obviously has its specific symptoms, for which reference is made to the fact sheets of the individual pathologies. In any case, some symptoms, especially if present simultaneously, may indicate the presence of an oncological condition:

  • Persistent fatigue
  • Nodules or thickening under the skin
  • Unexplained weight changes
  • Changes in the skin such as yellowish, dark, or reddened complexion, persistent
    inflammations, changes in the appearance of existing moles
  • Changes in bowel and bladder function
  • Persistent cough
  • Difficulty swallowing
  • Hoarseness
  • Persistent digestive difficulties, state of obstruction
  • Persistent and unexplained muscle or joint pains
  • Persistent and unexplained fever or night sweats

Bibliography:

  1. Izzotti A, Fracchia E, Rosano C, Comite A, Belgioia L, Sciacca S, Khalid Z, Congiu M, Colarossi C, Blanco G, Santoro A, Chiara M, Pulliero A. Efficacy of High-OzonideOil in Prevention of CancerRelapsesMechanisms and ClinicalEvidence. Cancers (Basel). 2022 Feb 24;14(5):1174. doi: 10.3390/cancers14051174. PMID: 35267482; PMCID: PMC8909345.

THE TUMOR: DOSAGE

USAGE:
O3ZONE FOOD
O3ZONE OIL
See the appropriate dosage in the
dosage indications.

ADMINISTRATION METHOD:
Enteric-coated capsules for systemic use orally
Ozonized oil for topical use

TREATMENT DURATION:
3-6 Months

EXCLUSION CRITERIA:
Pregnant women;
Internal and external bleeding;
Surgical interventions (discontinue treatment 3 days before and resume 7-10 days after);
Hyperthyroidism;
Glucose-6-phosphate dehydrogenase deficiency (favism).

TREATMENT OBJECTIVE:
The objective of the integrated treatment is to prevent recurrences, metastases, and
chemo-radio resistance and to maintain a consistently high oxidative level in oncological
patients.
Recommended as integrated therapy:
In patients with solid tumours.

Cancer refers to a group of over 200 diseases characterized by the uncontrolled proliferation of cells. Normally, our body is capable of controlling cell transformation processes, but when this capacity fails, the growth of cells that can invade surrounding tissues and even other organs can occur. Tumors can be solid or liquid. The latter fall into the category of leukaemias. Solid tumours can be benign or malignant. Benign tumours are composed of cells that reproduce uncontrollably but do not spread to other parts of the body.
Often, they can be surgically removed and, in most cases, do not recur. Malignant tumours can originate in a particular organ (the primary tumour) and spread through the lymphatic system or bloodstream to other, even distant, organs, causing the formation of secondary tumours or metastases. It is estimated that in 2019, in Italy, just over 371,000 new cases of malignant tumours will be diagnosed, of which about 196,000 (54%) in men and 175,000 (46%) in women.

The most common tumours in Italy are:

  • breast cancer (in women)
  • prostate cancer (in men)
  • lung cancer
  • colon-rectal cancer
    In the Italian population, it has been estimated that in 2019 there are approximately 3,460,000 people living after a
    cancer diagnosis.
    Some simple lifestyle changes can reduce the risk of developing cancer:
  • follow a healthy diet, rich in fruits and vegetables and low in animal fats and red meats
  • quit smoking
  • avoid excessive alcohol consumption
  • reduce overweight
  • increase physical activity

Cancer therapy is often surgical and involves the removal of a solid tumour.
Other types of interventions commonly used to fight cancer are:

  • chemotherapy, which involves the use of specific drugs called antineoplastics, capable of destroying or controlling tumour cells. In some cases, chemotherapy is used before surgery to reduce the size of the tumour. This is called neoadjuvant chemotherapy;
  • radiotherapy, which uses radiation to destroy cancer cells, trying to preserve the surrounding tissues as much
    as possible. The diagnosis of cancer sometimes requires several weeks or months. Since the tumour usually develops slowly over the course of years, a delay of a few weeks does not affect the effectiveness of treatments. If the family doctor suspects the presence of a tumour, it is advisable not to wait more than two weeks before consulting an oncologist specialist. Once the disease is confirmed, the treating physicians will indicate the most appropriate surgical, medical, and radiotherapeutic treatments and the timing of their initiation based on the type of tumour. Recent studies have shown the safety of using ozonides in cancer patients. These studies highlight how these substances can improve the therapeutic effectiveness of chemotherapy and prevent tumour recurrences. The role of O3zone is to support patients with ongoing or worsening diseases and in healed patients [1].Pharmacokinetic studies and publication in the journal “Cancers” have shown that 03zone is able to penetrate the cytoplasmic mitochondrion, selectively oxidizing the mitochondrion of neoplastic cells, causing the release of intracellular calcium with activation of programmed cell death (cell apoptosis) [2].

Bibliography:
[1l Izzotti A, Fracchia E, Rosano C, Comite A, Belgioia L, Sciacca S, Khalid Z, Congiu M, Colarossi C, Blanco G, Santoro A, Chiara M, Pulliero A. Efficacy of High-OzonideOil in Prevention of CancerRelapsesMechanisms and ClinicalEvidence. Cancers (Basel). 2022 Feb 24;14(5):1174. doi: 10.3390/cancers14051174. PMID: 35267482; PMCID: PMC8909345.
[2] Izzotti, A. Oxidative Drugs and microRNA: New Opportunities for Cancer Prevention. Cancers 2023, 15, 132. https://doi.org/10.3390/cancers15010132